Table 5.

Pharmacokinetic parameters of dose-normalized sildenafil in various groups.

Parameters	t1/2 (min)	C0 (μg/mL)	AUC (min μg/mL)	Cl (mL/min/kg)	Vss (L/kg)
Group 1	80 ± 34	5.6 ± 0.9	348 ± 44	27 ± 3.6	2710 ± 627
Group 2	84 ± 17	3.4 ± 0.8 *	183 ± 15*	55 ± 5.0	5400 ± 588
Group 3	54 ± 3.8	5.3 ± 0.9 †	296 ± 24 †	33 ± 2.8	2460 ± 98
Group 4a	61 ± 8.5	3.9 ± 0.8	178 ± 29 *,‡	57 ± 8.9	3790 ± 552
Group 5	55 ± 17	3.3 ± 1.3 *,‡	108 ± 34 *,†,‡,§	111 ± 70 *,‡	6540 ± 3760 *,‡
Group 6a	69 ± 17	3.1 ± 0.6 *,‡	147 ± 35 *,‡	73 ± 23	4790 ± 510

Group 1, sildenafil alone (10 mg/kg); group 2, low dose Epimedium sagittatum extract (1 g/kg) 2 hr pretreated + low dose sildenafil (10 mg/kg); group 3, low dose Epimedium sagittatum extract (1 g/kg/day) for 3 consecutive days and on day 4^th + low dose sildenafil (10 mg/kg); group 4, low dose Epimedium sagittatum extract (1 g/kg/day) for 3 consecutive days and on day 4^th + high dose sildenafil (30 mg/kg); group 5, high dose Epimedium sagittatum extract (2 g/kg/day) for 3 consecutive days and on day 4^th + low dose sildenafil (10 mg/kg); group 6, high dose Epimedium sagittatum extract (2 g/kg/day) for 3 consecutive days and on day 4^th + high dose sildenafil (30 mg/kg). Data are expressed as mean ± S. D. (n = 6). ^aC₀ and AUC was normalized to the dose of 10 mg/kg when statistical analysis was performed. ^*Intergroup difference between group 1 and other groups. ^† Intergroup difference between group 2 and other groups. ^‡ Intergroup difference between group 3 and other groups. ^§ Intergroup difference between group 4 and other groups.