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The yeast Osh3p ORD binds phosphatidylinositol-4-phosphate. (A) Binding of PI4P in the ORD. The two fatty acyl chains are inserted in the central hydrophobic tunnel, and the phosphoinositol head group is accommodated in a shallow basic cleft at the tunnel entrance. (B) The hydrophobic tunnel. The amino acid residues composing the wall of the tunnel are shown as ball-and-stick models. Reprinted with permission from Tong et al. [58] Copyright (2013) Elsevier Ltd.
