Figure 10.

(A) In vivo MRI of neovascularization 2 hours after injection of avb3-binding paramagnetic nanoparticles in lean, obese and obese treated mice. Contrast enhancement was increased in obese mice and was reduced to normal levels (of lean mice) after treatment with the appetite suppressant, benfluorex. (B) Staining of von Willebrand factor shows high density of neovessels in the adventitia of obese mice. (C) Quantification of adventitial microvessel density demonstrates a more than two fold increase in obese mice and a normalization after benfluorex treatment (adapted from Winter) [106].