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Ribosomal synthesis of bicyclic peptides. (a) Synthesis of an overlapped bicyclic peptide coupled with thioether and disulfide bond formations [45]. (b) Synthesis of a bicyclic peptide coupled with post-translational ring closure by a “click” cycloaddition reaction. The azide group of azidohomoalanine reacts with the alkyne group of propargylglycine to form a triazole moiety in a reaction catalyzed by Cu(I) [46].
