Table 3.
MRC components targeted |
MRC inhibitors applied |
C. neoformans 90112 |
C. gatti MYA-4560 |
C. albicans 90028 |
C. glabrata 90030 |
C. krusei 6258 |
---|---|---|---|---|---|---|
None | 6 | 6 | 6 | 6 | 6 | |
I | Rotenone | 3 | 4 | 6 | 6 | 6 |
II | Carboxin | 5 | 6 | 6 | 6 | 6 |
TTFA | 6 | 6 | 6 | 6 | 6 | |
3-NPA | 6 | 6 | 6 | 6 | 6 | |
AOX | BHAM | 6 | 6 | 6 | 6 | 6 |
SHAM | 6 | 6 | 6 | 6 | 6 | |
III | AntA | 4 | 6 | 6 | 6 | 6 |
Kre-Me | 3 | 5 | 6 | 6 | 6 | |
PCS | 3 | 4 | 6 | 6 | 6 | |
AZS | 4 | 6 | 6 | 6 | 6 | |
IV | KCN | 6 | 6 | 6 | 6 | 6 |
Na-azide | 3 | 4 | 6 | 6 | 6 |
a.TTFA, Thenoyltrifluoroacetone; 3-NPA, 3-Nitropropionic acid; BHAM, Benzhydroxamic acid; SHAM, Salicylhydroxamic acid; AntA, Antimycin A; Kre-Me, Kresoxim methyl; PCS, Pyraclostrobin; AZS, Azoxystrobin; KCN, Potassium cyanide; Na-azide, Sodium azide. Numbers represented highest dilution level (log10) where cell growth was visible. Numbers in bold show cell growth was inhibited (viz., < 6).