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. 2013 Mar 25;18(4):3674–3688. doi: 10.3390/molecules18043674

Scheme 1.

Synthesis of salicylanilides SAL and corresponding 4-(trifluoromethyl)benzoates 1 (R1 for esters: 1 = 4-Cl, 5-Cl, 4-Br; R2 = 3-Cl, 4-Cl, 3,4-diCl, 3-Br, 4-Br, 3-F, 4-F, 3-CF3, 4-CF3).

Scheme 1

Abbreviations: MW: microwave irradiation (530 W, 600 rpm, 20 min); Ph-Cl: chlorobenzene; DCC: N,N'-dicyclohexylcarbodiimide; DMF: N,N-dimethylformamide.