Figure 5.
IA inhibits phosphorylation of MAP kinases and AKT in FMLP-activated neutrophils. Neutrophils were treated with IA (3 μg/mL) for 5 min, and then activated with FMLP (30 nM) at 30 and 60 sec. Phosphorylation of MAP kinases and AKT was analyzed with sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting. Densitometric analysis of all samples was normalized to the corresponding total protein. All data are summarized as means ± SEM relative to the DMSO group, which activated by FMLP at 30 sec. (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001 versus the control group.
