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. 2013 Jul 24;18(8):8764–8778. doi: 10.3390/molecules18088764

Figure 5.

Figure 5

PA induced oxidative stress on A549 cells. (A) Fluorescence images acquired on the ArrayScan HCS Reader showing induction of p53 and p21 in the nucleus of A549 cells after 20 h incubation. Doxorubicin was included as positive control. While the untreated cells have minimal p53 or p21 signal, doxorubicin treated cells show bright p53 and p21 labeling in the cell nuclei; (B) PA induced p21 was evidenced with increased of the fluorescence signal; (C) PA induced p53 was evidenced with increased of the fluorescence signal.