Figure 1.

Long-term apigenin treatment improves learning and memory deficits in APP/PS1 mice. (A) Apigenin treatment attenuates the learning deficits compared with vehicle-treated APP/PS1 mice. (B) Apigenin increases the time a mouse spent in the target quadrant in the probe test. *** p < 0.001 vs. WT control mice, ^## p < 0.01 vs. APP/PS1 control mice. (C) Apigenin affects the numbers of crossings where the platform had been located in the probe test. * p < 0.05 vs. WT control mice. (D) No significant differences are observed in motor function of the apigenin-treated mice and the vehicle controls as reflected by the swimming speed. All data are presented as mean ± S.E.M., n = 9 mice per group.