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Apigenin treatment protects ERK/CREB/BDNF pathway of cerebral cortex in APP/PS1 mice. (A) Cerebral BDNF level in APP/PS1 mice detected by ELISA. (B,C) Representative immunoblots for p-ERK, total ERK, p-CREB and CREB and quantitative analysis for them. Data are presented as mean ± S.E.M., n = 4. ** p < 0.01 vs. WT control mice, # p < 0.05, ## p < 0.01 vs. APP/PS1 control mice.
