Table 1.
Leishmanicidal, trypanocidal and cytotoxic activities of maytenin (1) and pristimerin (2) in nanomolar.
| compound | L. amazonensis (IC50) | L. chagasi (IC50) | T. cruzi (IC50) | BALB/c (LC50) | ||
|---|---|---|---|---|---|---|
| promastigotes | amastigotes | promastigotes | amastigotes | epimastigotes | macrophages | |
| maytenin | 0.09 (243.65) | 0.47 (45.21) | 0.46 (46.41) | 0.25 (85) | 0.25 (85) | 21.25 |
| pristimerin | 0.05 (193.63) | 0.88 (11.03) | 0.41 (23.85) | 0.43 (22.65) | 0.30 (32.37) | 9.71 |
| control | 6.75 a (3.0) | 9.30 (2.18) | 6.75 a | n.d. | 31.20 × 103 | 20.32 a |
All IC50/LC50 values are in nM and selectivity indices (SI) are shown in parentheses; a, pentamidine; b, benznidazol; n.d. not determined.