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. 2013 Jan 15;18(1):1053–1062. doi: 10.3390/molecules18011053

Table 1.

Leishmanicidal, trypanocidal and cytotoxic activities of maytenin (1) and pristimerin (2) in nanomolar.

compound L. amazonensis (IC50) L. chagasi (IC50) T. cruzi (IC50) BALB/c (LC50)
promastigotes amastigotes promastigotes amastigotes epimastigotes macrophages
maytenin 0.09 (243.65) 0.47 (45.21) 0.46 (46.41) 0.25 (85) 0.25 (85) 21.25
pristimerin 0.05 (193.63) 0.88 (11.03) 0.41 (23.85) 0.43 (22.65) 0.30 (32.37) 9.71
control 6.75 a (3.0) 9.30 (2.18) 6.75 a n.d. 31.20 × 103 20.32 a

All IC50/LC50 values are in nM and selectivity indices (SI) are shown in parentheses; a, pentamidine; b, benznidazol; n.d. not determined.