Table 1.

Structures and cytotoxicity of compounds against HT-29, MDA-MB-231, U87MG, H460, A549, HL-60 and WI38 cell lines.

Compd.	R	IC50(μM) a
		MDA	HT29	U87MG	H460	A549	HL-60	WI38
3a	H	2.00	0.68	3.97	5.38	2.16	1.25	16.75
3b	3-chloro	1.61	0.78	3.51	7.32	4.48	0.75	23.88
3c	4-trifluoromethoxy	0.39	0.20	1.59	0.97	2.11	0.05	37.47
3d	2-fluoro-5-methyl	1.27	1.78	5.71	4.29	3.64	0.84	20.53
3e	2-methyl	1.64	0.86	2.73	1.58	7.32	2.37	16.44
3f	4-chloro	1.04	0.42	0.79	1.41	3.52	0.08	19.88
3g	2-chloro	0.93	0.55	1.78	2.53	3.05	0.17	16.33
3h	2,6-dichloro	1.07	0.49	2.51	1.28	4.33	0.14	20.74
6c	4-trifluoromethoxy	0.49	0.29	3.71	2.70	1.57	0.09	28.17
6b	3-chloro	2.23	1.11	4.52	2.79	2.86	1.81	35.76
6a	H	2.26	0.98	6.47	5.28	3.21	2.41	20.04
6d	2-fluoro-5-methyl	1.33	1.82	17.24	10.88	9.72	1.30	19.28
6e	2-methyl	2.10	2.09	3.65	1.92	5.47	3.21	16.39
6f	4-chloro	2.38	0.92	1.59	1.77	5.72	1.33	24.70
6i	3-methoxy	8.89	8.95	>100	16.32	11.34	8.53	19.21
6j	4-fluoro-3-trifluoromethyl	1.05	0.38	3.27	5.31	2.78	1.27	30.37
6g	2-chloro	0.72	0.45	2.69	0.89	5.31	0.27	27.20
6h	2,6-dichloro	0.88	0.44	3.12	1.21	2.34	0.18	23.5
DHA b		9.80	5.60	15.82	12.37	10.14	5.29	>100
Cisplatin b		6.82	10.31	8.21	7.55	4.31	9.28	51.22

NA: compound showing IC₅₀ value > 200 μM. ND: not determined. ^a IC₅₀: concentration of the compound (μM) producing 50% cell growth inhibition after 72 h of drug exposure, as determined by the MTT assay. Each experiment was run at least three times, and the results are presented as average values ± standard deviation. ^b Used as a positive control.