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. 2014 Jan 27;19(2):1394–1410. doi: 10.3390/molecules19021394

Table 2.

Antileishmanial activity and cytotoxicity (compounds 14–26 and 28).

graphic file with name molecules-19-01394-i007.jpg

IC50 (µM) *
Compd. R1 R2 R3 R4 R5 L. major promastigotes L. donovani promastigotes J774.1
14 graphic file with name molecules-19-01394-i008.jpg -H -H -Cl -Cl 65.6 >100 58.9
15 -H -H -H -H 39.6 15.6 45.2
16 -H -OCH3 -H -H 60.9 >100 42.6
17 -H -Cl -H -Cl 80.5 >100 60.6
18 graphic file with name molecules-19-01394-i009.jpg -H -H -H -H 64.3 51.2 46.0
19 graphic file with name molecules-19-01394-i010.jpg -H -H -H -H 55.0 >100 44.8
20 graphic file with name molecules-19-01394-i011.jpg -H -H -H -H 53.1 79.7 44.8
21 graphic file with name molecules-19-01394-i012.jpg -H -H -H -H 60.0 >100 46.7
22 graphic file with name molecules-19-01394-i013.jpg -H -H -H -H 67.0 28.7 44.5
23 graphic file with name molecules-19-01394-i014.jpg -H -H -H -H >100 23.4 >100
24 graphic file with name molecules-19-01394-i015.jpg -H -H -H -H >100 >100 >100
25 graphic file with name molecules-19-01394-i016.jpg -H -H -H -H >100 80.3 32.2
26 graphic file with name molecules-19-01394-i017.jpg -H -H -H -H >100 41.9 >100
28 graphic file with name molecules-19-01394-i018.jpg -OAc -OAc -H -H 30.7 - 2.1

* Positive control: pentamidine 82 μM (L. major), 38.6 μM (J774.1); miltefosine: 36.2 μM (L. major), 56.5 μM (J774.1); amphotericin B 0.4 μM (L. donovani).