Table 2.
Resistance and cross-resistance profile of CBAs of in vitro generated CBA-resistant HIV-1 strains.
CBAs | NL4.32G12res | IIIB2G12res | IIIBHHAres | IIIBGNAres | IIIBAHres | IIIBCV−Nres | NL4.3CV−Nres | NL4.3MVNres | IIIBBanLecres | IIIBGRFTres | IIIBUDAres |
---|---|---|---|---|---|---|---|---|---|---|---|
AH | N.D. a | N.D. | N.D. | N.D. | 19 b | N.D. | N.D. | N.D. | >66 | 118 | N.D. |
MVN | 2 | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | >100 | N.D. | 4 | N.D. |
2G12 mAb | >50 | >36 | >15 | >15 | >25 | >45 | >45 | >38 | >25 | >35 | >29 |
HHA | 12 | 2 | 919 | 490 | 1 | 17 | 4 | 3 | 3 | 5 | 117 |
GNA | 6 | 1 | 926 | 581 | N.D. | 23 | 1 | 2 | N.D. | N.D. | 39 |
BanLec | 1 | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | 5 | 24 | 13 | N.D. |
GRFT | 10 | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | 14 | >106 | >1900 | N.D. |
CV-N | 1 | 3 | 29 | 11 | N.D. | 20 | 7 | 4 | N.D. | N.D. | 83 |
OAA | 3 | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | 2 | 2 | 2 | N.D. |
UDA | 8 | N.D. | N.D. | N.D. | 1 | 1 | 3 | 3 | 1 | 3 | 24 |
Increased sensitivity |
1 (none) |
≥2–9 (low) |
≥10–24 (moderate) |
≥25–49 (high) |
≥50 (very high) |