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. 2014 Dec 15;19(12):21085–21112. doi: 10.3390/molecules191221085

Table 2.

Resistance and cross-resistance profile of CBAs of in vitro generated CBA-resistant HIV-1 strains.

CBAs NL4.32G12res IIIB2G12res IIIBHHAres IIIBGNAres IIIBAHres IIIBCV−Nres NL4.3CV−Nres NL4.3MVNres IIIBBanLecres IIIBGRFTres IIIBUDAres
AH N.D. a N.D. N.D. N.D. 19 b N.D. N.D. N.D. >66 118 N.D.
MVN 2 N.D. N.D. N.D. N.D. N.D. N.D. >100 N.D. 4 N.D.
2G12 mAb >50 >36 >15 >15 >25 >45 >45 >38 >25 >35 >29
HHA 12 2 919 490 1 17 4 3 3 5 117
GNA 6 1 926 581 N.D. 23 1 2 N.D. N.D. 39
BanLec 1 N.D. N.D. N.D. N.D. N.D. N.D. 5 24 13 N.D.
GRFT 10 N.D. N.D. N.D. N.D. N.D. N.D. 14 >106 >1900 N.D.
CV-N 1 3 29 11 N.D. 20 7 4 N.D. N.D. 83
OAA 3 N.D. N.D. N.D. N.D. N.D. N.D. 2 2 2 N.D.
UDA 8 N.D. N.D. N.D. 1 1 3 3 1 3 24
Notes: a: N.D. Not determined; b: Legend fold resistance: the indicated colors describe the antiviral activity [more- (shown in blue) or less active (shown in green-yellow-orange and red)] of various CBAs against different in vitro generated CBA-resistant HIV-1 strains.
Increased sensitivity
1 (none)
≥2–9 (low)
≥10–24 (moderate)
≥25–49 (high)
≥50 (very high)