Scheme 15.
Site-selective alkynylation of 51 and subsequent amination of 53.
Reagents and conditions: (i) PdCl2(PPh3)2, CuI, i-Pr2NH, THF, r.t., 3 h; (ii) 3-(6-methylpyridin-3-yloxy)-2-methyl benzenamine, t-BuOH, dichloroethane, 80 °C, 1 h.
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