Scheme 19.
Heck cross-coupling of 6-iodo-4-(isopropylamino)quinazolin-6-yl)acrylates 63.
Reagents and conditions: (i) alkene, NEt3, Pd(OAc)2, (o-Tol)3P, acetonitrile, 100 °C, 48–72 h.
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