Scheme 22.
Suzuki-Miyaura cross-coupling of bis-heterocycles 70 with arylboronic acids.
Reagents and conditions: (i) ArB(OH)2 (4.5 equiv.), PdCl2(PPh3)2, PCy3, K2CO3, dioxane–water (3/1, v/v), reflux, 5 h.
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