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. 2014 Sep 16;19(9):14649–14666. doi: 10.3390/molecules190914649

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© 2014 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

The effect of eurycomanone and eurycomanol on IκBα degradation and on p65 and p50 nuclear translocation. Jurkat cells were pre-treated with eurycomanone (45 μM) and with eurycomanol (100 μM) for two hours followed by activation with TNFα (20 ng/mL) for the indicated time periods. Cytoplasmic (A) and nuclear (B) extracts were tested for P-IκBα, IκBα, p50 and p65. Protein loading and purity of extracts were verified by lamin B and α-tubulin controls. Data are representative of three independent experiments.