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Depiction of the main interactions formed between the ligand (sticks), waters (sticks) and residues (lines) in the ATP-binding site of the CDK5D144N/p25 mutant. (a) Aloisine-A; (b) indirubin-3'-oxime; (c) R-roscovitine; (d) ATP and Mg2+. The dashed lines (blue) indicate H-bonding between the ligand and the surrounding protein and water molecules. The gate-keeper residue, F80, is shown in (a) and the residues which make up the hinge region in CDK5.
