Table 6.

In vivo binding specificity test and biodistribution of ⁶⁸Ga-NOTA-PEG₃-RM26 in female BALB/c nu/nu mice bearing PC-3 or BT-474 xenografts 2 h p.i. The data are presented as %ID/g ± SD, n = 4.

	PC-3 Cells		BT474 Cells
Organ	Non-Blocked	Blocked	Non-Blocked	Blocked
Blood	0.11 ± 0.02	0.060 ± 0.010 *	0.05 ± 0.02	0.17 ± 0.06
Liver	1.6 ± 0.1	1.6 ± 0.2	0.53 ± 0.06	0.81 ± 0.08
Spleen	1.4 ± 0.3	0.9 ± 0.3	0.3 ± 0.2	0.4 ± 0.1
Pancreas	3.9 ± 0.6	0.27 ± 0.04 *	2.8 ± 0.6	0.3 ± 90.04 *
Small intestine	1.2 ± 0.4	0.21 ± 0.08 *	0.66 ± 0.08	0.48 ± 0.09 *
Kidney	1.7 ± 0.2	3.3 ± 0.2 *	1.65 ± 0.09	4.25 ± 0.05 *
Tumor	4.6 ± 0.6	0.97 ± 0.04 *	2.8 ± 0.4	0.4 ± 0.1 *
Muscle	0.06 ± 0.02	0.030 ± 0.003	0.05 ± 0.02	0.13 ± 0.04
Bone	0.13 ± 0.03	0.13 ± 0.04	0.08 ± 0.03	0.14 ± 0.05

* Indicates that uptake was significantly lower in blocked than non-blocked groups.