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. 2014 Jul 28;19(8):10956–10981. doi: 10.3390/molecules190810956

Table 5.

Biological properties associated with the triterpenes with a focus on their potential chemotherapeutic applications.

No. Activity Ref.
1 Antisweet activity
Glucose uptake in rat small intestinal fragment
Increase of serum glucose level in oral glucose-loaded rats
Anti-hyperglycemic activity
[31,35,38]
[37,38]
[46,47]
[38]
2 Antisweet activity
Glucose uptake in rat small intestinal fragment
Increase of serum glucose level in oral glucose-loaded rats
Anti-hyperglycemic activity
[31,35,38]
[37,38]
[46,47]
[38]
3 Antisweet activity
Glucose uptake in rat small intestinal fragment
Increase of serum glucose level in oral glucose-loaded rats
Anti-hyperglycemic activity
[30,31,35,38]
[37,38]
[46,47]
[38]
4 Antisweet activity
Glucose uptake in rat small intestinal fragment
Increase of serum glucose level in oral glucose-loaded rats
Anti-hyperglycemic activity
Gut glycosidase inhibition
[30,31,35,38]
[37,38]
[46,47]
[38,65]
[38]
5 Antisweet activity
Increase of serum glucose level in oral glucose-loaded rats
Anti-hyperglycemic activity
Glucose uptake in rat small intestinal fragment
[32,38]
[46,47,65]
[38]
[38]
6 Antisweet activity [32]
7 Antisweet activity
Increase of serum glucose level in oral glucose-loaded rats
[32]
[46,47]
10 Antisweet activity [35]
11 Antisweet activity [35]
12 Antisweet activity [35]
13 Antisweet activity [35]
14 Antisweet activity [35]
15 Antisweet activity [36]
16 Antisweet activity [36]
17 Antisweet activity [36]
18 Antisweet activity [36]
19 Antisweet activity [31]
Pharmacokinetic study: determination of gymnemagenin in rat plasma using HPLC-MS/MS [66]
20 Antisweet activity [31]
27 Inhibition of the 11β-hydroxysteroid dehydrogenase type 1 [63,66]
28 Hypoglycemic and antihyperglycemic effect in rats [61]
29 Hypoglycemic and antihyperglycemic effect in rats [61]
30 Hypoglycemic and antihyperglycemic effect in rats [61]
31 Hypoglycemic and antihyperglycemic effect in rats [61]
32 Increase of serum glucose level in oral glucose-loaded rats [46,47]
33 Increase of serum glucose level in oral glucose-loaded rats [46,47]
34 Glucose uptake in rat small intestinal fragment [37]
35 Glucose uptake in rat small intestinal fragment [37]
36 Glucose uptake in rat small intestinal fragment [37]
37 Glucose uptake in rat small intestinal fragment [37]
39 Antisweet activity [34]
40 Antisweet activity
Glucose uptake in rat small intestinal fragment
[34]
[46,47]
41 Antisweet activity [34]
42 Antisweet activity
Glucose uptake in rat small intestinal fragment
[34]
[46,47]
43 Antisweet activity
Glucose uptake in rat small intestinal fragment
[34]
[37,47,59]
44 Inhibitory effects on human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15) in vitro using the sulforhodamine B (SRB) assay [55]
46 In vivo antitumor-promoting activity in mouse skin tumor [50]
Inhibition of the tumor-promoting action of 12-O-tetradecanoylphorbol 13-acetate [48,49]
Inhibition of phospholipid synthesis by 12-O-tetradecanoylphorbol-13-acetate [67]
In vitro in human uterus cancer cells
Anti-inflammatory activity and also to inhibit liver carcinogenesis and tumor growth [51]