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. 2018 Nov 24;24:8489–8499. doi: 10.12659/MSM.911202

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© Med Sci Monit, 2018

This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

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(A–D) The effects of klotho protein treatment on the activity of lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD), and reduced glutathione (GSH-PX) in human umbilical vein endothelial cells (HUVECs) after hydrogen peroxide (H₂O₂) treatment. Results are represented as the mean ±SD. Mod – the model group treated with 200 μmol/L of hydrogen peroxide (H₂O₂). The number of samples was five. ^# P<0.05. ^## P<0.01 vs. control. * P<0.05. ** P<0.01 vs. H₂O₂. ^@ P<0.05. ^@@ P<0.01 vs. 100 μg/L klotho protein. LY – LY294002, which is a PI3K inhibitor.