Table 1.
1H and 13C-NMR data for 1 and penostatin C (2).
| Position | 1 | Penostatin C (2) | ||
|---|---|---|---|---|
| δ(H) | δ(C) | δ(H) | δ(C) | |
| 1 | 194.7 | 197.8 | ||
| 2 | 5.95 (d, J = 2.4 Hz) | 113.8 | 5.87 (d, J = 2.4 Hz) | 115.7 |
| 3 | 174.6 | 173.8 | ||
| 4 | 6.54 (dt, J = 5.6; 2.3 Hz) | 131.4 | 6.52 (dt, J = 5.5; 2.4 Hz) | 131.6 |
| 5 | 6.87 (dt, J = 5.6; 2.3 Hz) | 150.9 | 6.82 (dt, J = 5.5; 2.3 Hz) | 149.4 |
| 6 | 2.90 (dddd, J = 16.9; 5.9; 1.5; 2.0 Hz) | 36.8 | 2.89 (dddd, J = 17.5; 6.5; 1.5; 2.0 Hz) | 36.2 |
| 2.52 (dddd, J = 16.9; 4.1; 1.5; 2.0 Hz) | 2.50 (dddd, J = 17.5; 4.2; 1.5; 2.0 Hz) | |||
| 7 | 2.99 (dddd, J = 10.8; 7; 3.7; 2.3 Hz) | 46.5 | 2.77 (dddd, J = 11.2; 6.8; 3.6; 2.5 Hz) | 45.7 |
| 8 | 2.28 (tq, J = 10.8; 1.9 Hz) | 44.9 | 2.49 (tq, J = 11.4; 2.2 Hz) | 44.9 |
| 9 | 91.9 | 4.44 (d, J = 11.1 Hz) | 74.9 | |
| 10 | 5.76 (m) | 119.7 | 5.67 (m) | 115.7 |
| 11 | 134.5 | 135.9 | ||
| 12 | 4.67 (d, J = 6.5 Hz) | 76.2 | 4.57 (d, J = 6.4 Hz) | 77.7 |
| 13 | 5.37 (dd, J = 6.5; 15.5 Hz) | 128.1 | 5.62 (dd, J = 6.6; 15.5 Hz) | 126.3 |
| 14 | 5.79 (dd, J = 15.5, 6.5 Hz) | 135.6 | 5.74 (dt, J = 15.5; 6.9 Hz) | 136.2 |
| 15 | 2.08 (m) | 31.8 | 2.09 (m) | 31.8 |
| 16 | 1.42 (m) | 28.7 | 1.31 (m) | 28.6 |
| 17 | 1.31 (brs) | 28.8 | 1.28 (brs) | 28.7 |
| 18 | 1.31 (brs) | 28.7 | 1.28 (brs) | 28.6 |
| 19 | 1.31 (brs) | 31.6 | 1.28 (brs) | 31.6 |
| 20 | 1.31 (brs) | 22.3 | 1.28 (brs) | 22.3 |
| 21 | 0.91(t, J = 6.8 Hz) | 12.9 | 0.88(t, J = 6.8 Hz) | 13.0 |
| 22 | 1.65 (s) | 18.2 | 1.59 (s) | 18.7 |
Note: 1 and 2 were measured in CDCl3. Assignments made on the basis of 1H, 1H-COSY, HMQC and HMBC experiments.