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. 2014 Jul 10;19(7):10074–10089. doi: 10.3390/molecules190710074

Figure 2.

Figure 2

Conserved Domains of Nrf2 and Keap1 Proteins. (A) Nrf2 contains seven Neh domains (Neh1-7), in which the Neh1 domain binds to DNA using the bZIP motif and the Neh2 domain interacts with Keap1 using the DLG and ETGE motifs. The Neh4 and Neh5 domains are required for gene transactivation. The Neh6 domain binds to β-TrCP using DSGIS and DSAPGS motifs. The Neh7 domain binds to RARα and suppresses the Nrf2 activity; (B) Keap1 contains five different domains (NTR, BTB, IVR, DGR and CTR), in which the BTB domain forms a homodimer for binding to Cullin-3 and the DGR domain forms a six-blade propeller with 6x Kelch motifs for the interaction with Nrf2.