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Effect of compounds 1, 8 and 12 on chromatin condensation and fragmentation. CoN, MCF-7 and PC-3 cells treated with one of the compounds were stained with Hoechst 33342 (200×). Representative photographs presented here show nuclear morphologic changes observed by fluorescent microscopy of the treated cells. As positive control, 5-fluorouracyl (25 μM) was used.
