. 2014 Dec 16;19(12):21200–21214. doi: 10.3390/molecules191221200

Table 2.

Comparison of affinity of purine nucleosides and corresponding fleximers for T. brucei transporters.

graphic file with name molecules-19-21200-i001.jpg

	P1 K_i (μM)			P2 K_i (µM)
	Nucleoside ¹	Fleximer	δ(ΔG⁰)	Nucleoside ¹	Fleximer	δ(ΔG⁰)
Adenosine	0.36 ± 0.05	35 ± 11	11.4	0.91 ± 0.29	37 ± 3	9.2
Guanosine	1.8 ± 0.3	251 ± 75	12.2	>500	>500
Inosine	0.44 ± 0.10	387 ± 30	16.8	>500	>500

Data are the average inhibition constants (K_i) and SEM of at least three independent experiments; Values for adenosine are Michaelis-Menten constants (K_m). ¹ values were taken from previous findings of De Koning [47] and included here for comparison; δ(ΔG⁰) is the difference in Gibbs free energy of interaction of the nucleoside and the fleximer with the transporter, given in kJ/mol.