Table 1.
Murine P388 lymphocytic leukemia inhibitory activity of ritterazines and cephalostatins.
| Ritterazine | (ED50 nM) | Cephalostatin | (ED50 nM) | Ritterazine | (ED50 nM) | Cephalostatin | (ED50 nM) |
|---|---|---|---|---|---|---|---|
| A | l4.2 | 1 | 10−4–10−6 | N | 522 | 14 | 4.4 |
| B | 0.17 | 2 | 10−4–10−6 | O | 2383 | 15 | 26.2 |
| C | 102.3 | 3 | 10−4–10−6 | P | 819 | 16 | <1.1 |
| D | 17.5 | 4 | 10−4–10−6 | Q | 657 | 17 | 4.4 |
| E | 3.8 | 5 | 42.5 | R | 2461 | 18 | 4.6 |
| F | 0.81 | 6 | 2.3 | S | 539 | 19 | 7.9 |
| G | 0.81 | 7 | 1–<0.1 | T | 522 | ||
| H | 17.8 | 8 | 1–<0.1 | U | 2341 | ||
| I | 15.3 | 9 | 1–<0.1 | V | 2341 | ||
| J | 14.0 | 10 | 3.2 | W | 3631 | ||
| K | 10.4 | 11 | 2.7 | X | 3404 | ||
| L | 11.1 | 12 | 76.2 | Y | 4.0 | ||
| M | 16.7 | 13 | 47.9 | Z | 2200 |