Table 1.
In vitro antileishmanial activities of sesquiterpene lactones from T. diversifolia against L. braziliensis promastigotes and cytotoxic effects on peritoneal macrophages.
| Compounds | LD50 for Leishmania µg·mL−1/µM | LD50 for macrophages µg·mL−1 | Selectivity Index |
|---|---|---|---|
| 1 | 3.2 ± 0.5/9.2 ± 1.4 | 4.5 ± 0.9 | 1.4 |
| 2 | 2.2 ± 0.9/6.0 ± 2.5 | >50.0 | >22.7 |
| 3 | >50.0 | >50.0 | - |
| 4 | 8.7 ± 1.9/24.7 ± 5.4 | 24.9 ± 1.1 | 2.9 |
| 5 | 13.7 ± 2.6/37.4 ± 7.1 | >50.0 | >3.6 |
| 6 | 7.4 ± 2.8/21.2 ± 8.0 | >50.0 | >6.7 |
| 7 | 9.0 ± 1.2/24.6 ± 3.3 | >50.0 | >5.5 |
| 8 | 7.5 ± 3.2/20.4 ± 8.7 | >50.0 | >6.6 |