Table 1.
Inhibition of recombinant human Monoamine Amine Oxidase-A and B by propolis extract, fractions and pure constituents.
| Sample Name | Unit | Monoamine Oxidase-A (IC50) * | Monoamine Oxidase-B (IC50) * |
|---|---|---|---|
| Propolis Extract (prop-E) | μg/mL | 0.60 ± 0.12 | 6.99 ± 0.09 |
| Fraction 2 (9.0–17.5 min) # | μg/mL | 0.33 ± 0.03 | 0.31 ± 0.02 |
| Fraction 3 (17.5–20 min) # | μg/mL | 0.16 ± 0.11 | 0.23 ± 0.09 |
| Fraction 4 (20–30 min) # | μg/mL | 5.36 ± 0.22 | 0.98 ± 0.08 |
| Fraction 5 (30–35 min) # | μg/mL | 26.16 ± 0.29 | 22.19 ± 3.34 |
| Galangin | μM | 0.13 ± 0.01 | 3.65 ± 0.150 |
| Apigenin | μM | 0.64 ± 0.11 | 1.12 ± 0.27 |
| Quercetin | μM | 2.44 ± 0.12 | 38.66 ± 1.20 |
| Fisetin hydrate | μM | 2.10 ± 0.09 | >100 |
| Morin hydrate | μM | 5.88 ± 0.15 | 49.66 ± 0.56 |
| Toxifolin | μM | 65.06 ± 1.96 | 53.80 ± 3.91 |
| Clorgyline | μM | 0.0065 ± 0.0003 | - |
| Deprenyl | μM | - | 0.036 ± 0.0012 |
| Harmine | μM | 0.0039 ± 0.0003 | 27.50 ± 2.67 |
* The IC50 values computed from the dose response inhibition curves are Mean ± S.D. of triplicate observations. # Retention time (Tr values, indicate time for start and end for collection of the fraction. See Figure S1, Supplementary Data.