Table 2.
Inhibition/binding affinity constants (Ki) values for inhibition of recombinant human MAO-A and B by galangin and apigenin.
| Compound | Monoamine Oxidase-A | Monoamine Oxidase-B | ||
|---|---|---|---|---|
| Ki (μM) * | Type of Inhibition | Ki (μM) * | Type of Inhibition | |
| Galangin | 0.029 ± 0.004 | Competitive/Reversible | 1.998 ± 0.039 | Competitive/Reversible |
| Apigenin | 0.125 ± 0.014 | Competitive/Reversible | 0.238 ± 0.024 | Competitive/Reversible |
| Harmine | 0.0019 ± 0.0002 | Competitive/Reversible | - | - |
| Clorgyline | 0.0026 ± 0.006 | Mixed/Irreversible | - | - |
| Deprenyl | - | - | 0.0301 ± 0.003 | Mixed/Irreversible |
* Values are mean ± S.D. of triplicate experiments.