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. 2014 Aug 15;19(8):12368–12420. doi: 10.3390/molecules190812368

Scheme 5.

Total synthesis of enniatin B (40) by Ley et al.

Scheme 5

Reagents and conditions: (a) EDCI, DMAP, CH2Cl2 (82%); (b) H2, Pd/C, EtOAc (100%); (c) 4 M HCl/1,4-dioxane (100%); (d) Ghosez's reagent (1-chloro-N,N,2-trimethyl-1-propenylamine), DIPEA, CH2Cl2 (91%); (e) 65, Ghosez's reagent, DIPEA, CH2Cl2, (86%); (f) H2, Pd/C, EtOAc (88%); (g) Ghosez's reagent, DIPEA, 0.005 M CH2Cl2 (56%).