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Total synthesis of paecilodepsipeptide A 176.
Reagents and conditions: (a) EDCl/HOBt/Et3N/CH2Cl2, 89%; (b) H2, Pd/C; (c) 179 EDCl/HOBt/Et3N/CH2Cl2, 86%; (d) EDCl/HOBt/Et3N/CH2Cl2, 90%; (e) H2, Pd/C MeOH; (f) EDCl/HOBt/Et3N/CH2Cl2, 76%; (g) 184, EDCl/HOBt/Et3N/CH2Cl2, 75%; (h) TBAF/THF; (i) HATU/DIPEA/DM, 72%.
