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Biological activities of zygosporamide analogues.
| Compound | IC50 (µM) | ||||
|---|---|---|---|---|---|
| SF-268 | SF-295 | A549 | MDA-MB-231 | HCT-116 | |
| Zygosporamide (26) | 0.0065 | 15 | 7.4 | 8.5 | 11.5 |
| 31 | ~35 | 19.7 ± 8.8 | ~31 | 7.5 ± 6.3 | >50 |
| 32 | 10.4 ± 1.5 | 8.7 ± 0.9 | >50 | 5.0 ± 1.8 | 2.1 ± 0.4 |
| 33 | >50 | >50 | >50 | >50 | >50 |
| 34 | 8.8 ± 1.5 | ~6 | >50 | 2.8 ± 2.1 | 2.7 ± 0.6 |
| 35 | ~31 | ~32 | >50 | >50 | 7.8 ± 6.0 |
| 36 | 2.05 ± 2.0 | 14.4 | 21.0 ± 5.9 | >50 | 1.9 ± 1.3 |
