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PPARγ antagonist GW9662 substantially abolished sesamin-mediated cholesterol efflux from RAW264.7 macrophages. Cells were treated with rosiglitazone (1 μM), sesamin (10 μM), GW9662 (10 μM) or sesamin + GW9662 (10 μM + 10 μM) for 6 h after incubation with 25-NBD cholesterol for 24 h. Values represent mean ± SD. Results are representative of three different experiments. * p < 0.05, ** p < 0.01 versus control group.
