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Synthesis routes to TOA-amino acid derivatives.
Reagents and conditions: (a) EDCI, DAMP, r.t.12 h, 45%–90%; (b) 3 M HCl/ethyl acetate solution, r.t.1 h, 90%; (c) 10% Pd/C or Pd(OH)2/C, H2, r.t.12 h, 96%; (d) TBDMS-Cl, imidazole, DMF, r.t.12 h; (e) TBAF, dry THF, ice-salt bath, 0.5 h.
