Table 3.

SAR of Cdc7 inhibitors 37–40.

Compound	R	IC50 Cdc7 (μM)	IC50 CDK2 (μM)	Compound	IC50 Cdc7 (μM)	IC50 CDK2 (μM)
37a	H	0.98	3.7	38	0.066	3.7
37b	C6H4	0.10	0.31	39	0.66	38
37c	2-ClC6H4	0.011	0.11	40	0.03	>80
37d	3-ClC6H4	0.16	>83
37e	4-ClC6H4	0.33	0.06
37f	3-pyridinyl	0.16	1.1
37g	3-(2-Clpyridinyl)	0.007	0.31
37h	4-pyridinyl	0.25	0.16
37i	3-furanyl	0.12	0.10
37j	3-pyrazole	0.58	0.55