Figure 4.

Left: Schematic presentation of the rectangular DNA origami platform used to study singlet oxygen production, diffusion and bond cleavage. Singlet oxygen is produced by an IPS photosensitizer in the center and induces bond cleavage in the SOC linkers placed at different distance from the IPS. After UV-irradiation and thus reaction with singlet oxygen SAv is added, which binds to the remaining strands to visualize them for AFM analyses. On the right examples of AFM images are shown. (a) Non-irradiated DNA origami platforms with the SOC linkers and one marker in the corner of the rectangle. A zoom-in is shown in (b). UV irradiation results in singlet oxygen production and cleavage of the SOC linkers, which is shown in (c,d). Adapted with permission from Ref. [25]. Copyright 2010 American Chemical Society.