Table 1.

Effects of resveratrol on adipogenesis in in vitro studies.

Authors	Experimental Design	Effects
Kwon et al. (2012) [16]	3T3-L1 pre-adipocytes	↓ C/EBPα, PPARγ protein expression ↓ Mitotic clonal expansion
	25, 50 µM
	24 h
Chen et al. (2011) [17]	3T3-L1 pre-adipocytes	↓ PPARγ, C/EBPα, SREBP-1c mRNA expression
	20, 40, 80 µM
	24, 48 h
Rayalam et al. (2008) [18]	3T3-L1 pre-adipocytes	↓ PPARγ, C/EBPα, SREBP-1c and FAS, LPL mRNA
	25 µM6 days
	6 days
Kang et al. (2012) [19]	3T3-L1 pre-adipocytes	↓ Lipid accumulation ↓ C/EBPβ, PPARγ, C/EBPα, FABP4 protein expression
	10, 20, 40 µM
	2, 4, 6 days
Lasa et al. (2012) [20]	3T3-L1 pre-adipocytes	↓ Triacylglycerol content by resveratrol, trans-resveratrol-4-O'-glucuronide, trans-resveratrol-3-O-sulfate ↓ C/EBPβ mRNA ↓ C/EBPα, PPARγ mRNA by trans-resveratrol-3-O-sulfate
	1, 10, 25 µM resveratrol and its metabolites (trans-resveratrol-3-O-glucuronide, trans-resveratrol-4-O'-glucuronide, trans-resveratrol-3-O-sulfate)
	8 days
Hu et al. (2014) [21]	3T3-L1 pre-adipocytes	↑ C/EBPα, PPARγ and FABP4 mRNA expression at 1 and 10 µM ↓ C/EBPα, PPARγ and FABP4 mRNA expression at 50 and 100 µM
	1, 10, 50, 100 µM
	7 days
Carpéné et al. (2014) [22]	3T3 F442A pre-adipocytes	↓ Mitotic clonal expansion
	20 µM
	8 days
Bai et al. (2008) [23]	Pig primary pre-adipocytes	↑ SIRT-1 mRNA ↓ FOXO1 and PPARγ2 mRNA expression
	100 µM
	72 h
Fisher-Posovszky et al. (2010) [24]	Human Simpson-Golabi-Behmel Syndrome pre-adipocytes	↓ PPARγ, GLUT4 and FAS mRNA expression
	10, 30, 50, 100 µM
	4 days

C/EBP: CCAAT/enhancer-binding protein; PPARγ: Peroxisome proliferator-activated receptor gamma; SREBP1: Sterol regulatory element binding protein 1; FAS: Fatty acid synthase; LPL: Lipoprotein lipase; FABP4: Fatty acid binding protein.