Table 3.

Effects of resveratrol on de novo lipogenesis and lipoprotein lipase in in vitro and in vivo studies.

Authors	Experimental Design	Effects
Lasa et al. (2012) [22]	3T3-L1 pre-adipocytes	↓Triacylglycerol content ↓ACC mRNA expression ↑SIRT-1 mRNA expression
	1, 10, 25 µM resveratrol and its metabolites (trans-resveratrol-3-O-glucuronide, trans-resveratrol-4-O'-glucuronide, trans-resveratrol-3-O-sulfate)
	24 h
Szkudelska et al. (2009) [43]	Rat primary adipose culture from epididymal	↓ Basal lipogenesis from glucose
	62.5, 125, 250 µM
	90 min
Rivera et al. (2009) [44]	Male Zucker rats	↓Abdominal fat ↑pACC protein expression ↑AMPK
	10 mg/kg body weight/day
	8 weeks
Gómez-Zorita et al. (2013) [45]	Male Zucker rats	↓ Final body weight and internal fat depots ↓ G6PDH = FAS, ME ACC ↓ LPL activity, = LPL mRNA expression
	15 mg/kg body weight/day
	6 weeks
Nagao et al. (2013) [46]	OLETF rats	↓ Abdominal fat depot = FAS mRNA expression
	0.5% resveratrol
	4 weeks
Alberdi et al. (2011) [47]	Male Sprague-Dawley rats	↓ Perirenal, epididymal, mesenteric and subcutaneous fat depots ↓ ACC, FAS, G6PDH activities
	30 mg/kg body weight/day
	6 weeks
Arias et al. (2014) [48]	Male Wistar rats	↓ FAS and LPL activities
	30 mg/kg body weight/day
	6 weeks
Kim et al. (2011) [49]	C57BL/6J mice	↓ Adipose tissue weight ↓ SREBP-1c, FAS mRNA expression = PPARγ mRNA expression
	0.4% resveratrol
	10 weeks
Cho et al. (2012) [50]	C57BL/6J mice	↓ Visceral adipose tissue weight ↓ FAS, G6PDH
	0.005 and 0.02% resveratrol
	10 weeks
Qiao et al. (2014) [51]	Kumming mice	↓ ACC, FAS mRNA expression
	200 mg/kg/d
	12 weeks
Azorin-Ortuño et al. (2012) [52]	PBMCs of pigs	↓ LPL mRNA expression
	0.11 mg/kg body weight/d
	12 months

ACC: acetyl-CoA carboxylase; SIRT1: sirtuin 1; pACC: phosphorylated ACC; G6PDH: glucose-6 phosphate dehydrogenase; FAS: fatty acid synthase; ME: malic enzyme; LPL: lipoprotein lipase; SREBP1: sterol regulatory element binding protein 1.