Table 5.

Effects of resveratrol on thermogenesis in in vivo studies.

Authors	Experimental Design	Effects
Alberdi et al. (2013) [69]	Male Sprague-Dawley rats 30 mg/kg body weight/day 6 weeks	IBAT ↑ UCP1 ↑ SIRT-1, PGC-1α and TFAM mRNA expression Skeletal muscle ↑ UCP3 ↑ TFAM mRNA expression
Lagouge et al. (2006) [72]	Mice	Skeletal muscle ↑ UCP3 ↑ SIRT-1, PGC-1α and TFAM mRNA expression
	400 mg/kg body weight/day
	15 weeks
Oliveira et al. (2014) [73]	Mice 1000 mg/kg body weight/day 8 weeks	IBAT ↑ UCP1 =UCP3 ↑ SIRT-1

IBAT: Interscapular brown adipose tissue; UCP: Uncoupling protein; SIRT-1: Sirtuin 1; PGC-1α: Proliferator-activated receptor-gamma coactivator 1α; TFAM: Mitochondrial transcription factor A.