Table 1.
Composition of samples, concentration (%) of individual excipients in water samples relative to risedronate, particle size (nm) and polydispersity index (PDI) of risedronate samples expressed as mean ± SD (n = 5 independent measurements). (SDS = sodium dodecyl sulfate, PLS = polysorbate 80, PEG = macrogol 6000, SCMC = sodium carboxymethyl cellulose, SCMD = sodium carboxymethyl dextran, DSP = sodium dodecyl sulfate/macrogol 6000).
| Sample | Excipient/Concentration (%) | Particle Size (nm) | PDI |
|---|---|---|---|
| 1a | SDS/1 | 95.6 ± 11.2 | 0.263 ± 0.030 |
| 1b | SDS/3 | 194.8 ± 34.6 | 0.377 ± 0.056 |
| 1c | SDS/5 | 75.4 ± 3.4 | 0.285 ± 0.022 |
| 2a | PLS/1 | 10.5 ± 0.3 | 0.173 ± 0.048 |
| 2b | PLS/3 | 10.1 ± 0.3 | 0.086 ± 0.043 |
| 2c | PLS/5 | 9.9 ± 0.1 | 0.139 ± 0.017 |
| 3a | PEG/1 | 9.1 ± 1.9 | 0.532 ± 0.095 |
| 3b | PEG/3 | 8.2 ± 1.1 | 0.401 ± 0.066 |
| 3c | PEG/5 | 7.7 ± 2.5 | 0.315 ± 0.028 |
| 4a | SCMC/1 | 12.9 ± 2.4 | 0.685 ± 0.101 |
| 4b | SCMC/3 | 2946.7 ± 367.6 | 0.560 ± 0.048 |
| 4c | SCMC/5 | 7287.6 ± 1352.5 | 0.651 ± 0.151 |
| 5a | SCMD/1 | 3.5 ± 1.1 | 0.473 ± 0.156 |
| 5b | SCMD/3 | 2.8 ± 0.4 | 0.287 ± 0.050 |
| 5c | SCMD/5 | 3.8 ± 1.2 | 0.244 ± 0.135 |
| 6a | DSP/1 | 110.1 ± 7.4 | 0.578 ± 0.029 |
| 6b | DSP/3 | 122.7 ± 7.4 | 0.524 ± 0.037 |
| 6c | DSP/5 | 4.00 ± 0.8 | 0.310 ± 0.033 |