Scheme 2.
Preparation of the alkyne 9 for the click reaction.
Reagents and conditions: (a) NaOH 50%, 99%; (b) AcSH, THF, 71%; (c) Conc. HCl, EtOH; (d) MeOTrCl, THF, 91%; (e) 2-bromopropyne, NaH, THF, 97%.
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