Figure 1.

The real ligand (red, hydroxyapatite) binding site and the identified sites on different modules of FN-III_7–10 (PDB ID: 1PNF). The pocket sites (white) of LIGSITECS, PASS, SURFNET, Q-SiteFinder, Fpocket, ConCavity, GHECOM and POCASA are all from their top 1 predictions and are located in the same cavity where ligand binds. The meta-Pocket site from MPK2 is shown in red sphere. (a) FN-III₁₀, (b) FN-III_9–10, (c) FN-III_8–10 and (d) FN-III_7–10.