Table 3.
Median (range) and areas under the ROC curve (AUCs, 95% confidence interval) of baseline cortisol, post‐ACTH stimulation cortisol, ratio and delta (post‐to‐baseline) serum cortisol concentrations in the diagnosis of pituitary‐dependent hyperadrenocorticism
| Median (range) | ROC curve | ||||
|---|---|---|---|---|---|
| HAC | NAI | AUC | 95% CI | P a | |
| Post‐ACTH stimulation cortisol | 0.92 | 0.81‐0.98 | ‐ | ||
| (nmol/L) | 878 (208‐1753) | 529 (244‐718) | |||
| (μg/dL) | 31.8 (7.5‐63.5) | 19.2 (8.8‐26.0) | |||
| Baseline cortisol | 0.70 | 0.56‐0.82 | .01 | ||
| (nmol/L) | 147 (61‐600) | 113 (19‐263) | |||
| (μg/dL) | 5.3 (2.2‐21.7) | 4.1 (0.7‐9.5) | |||
| Delta cortisol | 0.86 | 0.74‐0.94 | .09 | ||
| (nmol/L) | 730 (134‐1601) | 396 (218‐658) | |||
| (μg/dL) | 26.4 (4.8‐58.0) | 14.3 (7.9‐23.8) | |||
| Ratio cortisol | 0.55 | 0.41‐0.69 | <.001 | ||
| 6.9 (1.6‐15.0) | 5.4 (0.4‐30.4) | ||||
a
P value for comparison of each AUC with post‐stimulation cortisol AUC.