Table 4.

Quantification studies of (4R,8aR)-3a and (4S,8aS)-6 in the 6 Hz and neurotoxicity tests following intraperitoneal (ip.) administration in mice.

Compound	ED50 6 Hz (mg/kg)	TD50 (mg/kg) a	PI b 6Hz	TPE c (h)
(4R,8aR)-3a	47.90 (35.6–71.08)	277.09 (245.78–350.13)	5.8	0.25
(4S,8aS)-6	126.19 (105.87–145.68)	262.22 (242.15–290.77)	2.1	0.25
1 d	9.93 (5.97–14.55)	121.5 (104.9–142.8)	12.2	0.25
Phenytoin e	>60	41.0 (39.4–43.0)	-	-
Phenobarbital e	14.8 (8.9–23.9)	69.0 (62.8–72.9)	4.7	0.5
Ethosuximide e	167 (114–223)	341 (290–384)	2.0	0.25
Levetiracetam e	19.4 (9.90–36.0)	>500	>25.8	1.0

Values in parentheses are 95% confidence intervals determined by probit analysis; ^a Neurotoxicity; ^b Protective index (TD₅₀/ED₅₀ 6 Hz); ^c Time to peak effect for the 6Hz test; ^d Data from Ref. [8]; ^e Data from Ref. [25]