Skip to main content
. 2014 Oct 24;19(11):17078–17106. doi: 10.3390/molecules191117078

Scheme 1.

The alternative biosynthetic and degradative pathways of AEA and congeners.

Scheme 1

Notes: NAAA, N-acylethanolamine-hydrolyzing acid amidase; NArPE, N-arachidonoyl- phosphatidylethanolamine; pNArPE, N-arachidonoylethanolamine plasmalogen; ABHD4, α/β-hydrolase 4; NAPE-PLD, N-acyl-phosphatidylethanolamines-hydrolyzing phospholipase D; AA, arachidonic acid; COX-2, cyclooxygenase-2; Cyt P450, cytochrome P450; EET-EA, epoxyeicosatrienoyl ethanolamides; EtNH2, ethanolamine; FAAH, fatty acid amide hydrolase; GP-AEA, glycerophospho-AEA; GDE1, glycerophosphodiester phosphodiesterase 1; 12-HAEA, 12-hydroxyanandamide; lyso-NArPE, lyso-N-arachidonoylphosphatidylethanolamine; 12-LOX, 12-lipoxygenase; pAEA, phospho-AEA ; NAT, N-acyl-transferase; iNAT, Ca2+-independent N-acyltransferase; PMF2α, prostamides F2α; PLA2, phospholipase A2; PLC, phospholipase C; lyso-PLD, lyso-phospholipase D; PTPN22, protein tyrosine phosphatase, non-receptor type 22.