Table 2:
A summary of some cerebellar focused imaging studies exploring various pathologies. We include whether the study used manual delineations (MD) and the key cerebellar related findings. N (M/F) denotes the number of patients and the male/female ratio. Abbreviations: ADHD - Attention-deficit and hyperactivity disorder; AD - Alzheimer’s disease; AS - Asperger syndrone.
| Disease | Citation | N (M/F) | MD | Observations |
|---|---|---|---|---|
| ADHD | Mostofsky et al. (1998b) | 35 (35/0) | Y | Decreased inferior posterior vermis |
| Durston et al. (2004) | 90 (90/0) | N | Reduced right cerebellar volume | |
| Alcoholism | Torvik and Torp (1986) | 65 (65/0) | Y | Decreased vermis segments |
| Baker et al. (1999) | 19 (14/5) | Y | Non-significant loss in vermis and flocculus | |
| AD | Thomann et al. (2008) | 60 (29/31) | Y | Decreased superior and inferior posterior lobes |
| Möler et al. (2013) | 344 (175/169) | –† | Reduced GM throughout the cerebellum | |
| Colloby et al. (2014) | 127 (84/43) | –† | Bilateral reduction of Lobule VI | |
| AS | Catani et al. (2008) | 31 (31/0) | Y | Reduced cerebellar fractional anisotropy |
| Autism | Courchesne et al. (1994) | 103 (84/19) | Y | Reduced area in the vermis of Lobule VI and VII |
| Cleavinger et al. (2008) | 65 (65/0) | Y | No significant differences | |
| Webb et al. (2009) | 71 (56/15) | Y | Reduced area in various vermal labels | |
| D’Mello et al. (2015) | 70 (51/19) | N | Reduced GM in Lobule VII | |
| Dyslexia | Brambati et al. (2004) | 21 (10/11) | –† | Reduced cerebellar GM volume |
| Jednoróg et al. (2013) | 81 (39/42) | –† | Reduced GM volume in left Lobule I/II | |
| Fragile X Syndrome | Mostofsky et al. (1998a) | 188 (98/90) | Y | Decreased posterior vermis in males and females, though less significant in females. |
| Schizophrenia | Nopoulos et al. (1999) | 130 (130/0) | N‡ | Smaller vermis area and smaller anterior lobe |
| Okugawa et al. (2002) | 30 (30/0) | N‡ | Reduced posterior superior vermis | |
| Okugawa et al. (2003) | 116 (73/43) | N‡ | Reduced anterior vermis, posterior superior vermis, and posterior inferior vermis volumes | |
| Womer et al. (2016) | 104 (48/56) | Y | Decreased posterior vermis volumes in males |
†
The studies did not differentiate regions of the cerebellum and based assessment on an anatomists interpretation of the areas of change.
‡
Automated processing for cerebellar volumes based on registration to a Talairach Atlas, augmented by manual tracings of the vermis.