Table 4.
Antiproliferative activity of cocoa plant part extracts.
| Plant Part | IC50 (μg/mL) * | ||||||
|---|---|---|---|---|---|---|---|
| A549 | HeLa | HepG2 | HT-29 | MCF-7 | MDA-MB-231 | WRL-68 | |
| Leaf | 541.3 ± 69.8 | 430.7 ± 82.2 | 493.3 ± 17.2 | 559.0 ± 16.0 | 41.4 ± 3.3 | 504.3 ± 30.2 | 765.00 ± 34.0 |
| Bark | 574.7 ± 48.8 | 688.7 ± 64.8 | 828.3 ± 154.0 | 468.7 ± 22.2 | 72.0 ± 9.3 | 555.3 ± 36.2 | 842.67 ± 66.5 |
| Husk | 533.7 ± 63.5 | 372.7 ± 16.5 | 396.0 ± 40.4 | 443.3 ± 23.4 | 62.2 ± 14.9 | 550.7 ± 6.7 | 792.33 ± 75.5 |
| Unfermented shell | 613.7 ± 25.9 | 468.3 ± 36.0 | 464.3 ± 42.8 | 163.0 ± 18.6 | 65.0 ± 4.2 | 555.0 ± 10.1 | 97.90 ± 1.3 |
| Fermented shell | 520.7 ± 19.1 | 71.4 ± 12.1 | 68.9 ± 10.2 | 197.0 ± 13.2 | 242.3 ± 47.7 | 486.3 ± 13.0 | 633.33 ± 119.8 |
| Pith | 595.0 ± 82.6 | 868.0 ± 13.6 | 951.0 ± 13.8 | 530.3 ± 41.1 | 329.7 ± 52.7 | 360.0 ± 34.8 | 489.00 ± 50.6 |
| Root | 636.3 ± 66.4 | 321.7 ± 26.0 | 237.3 ± 19.0 | 613.3 ± 60.2 | 76.4 ± 13.8 | 400.3 ± 74.6 | >1000.0 |
| Cherelle | 639.7 ± 45.7 | 67.8 ± 9.4 | 427.3 ± 31.4 | 629.3 ± 37.8 | 68.9 ± 11.4 | 614.7 ± 11.3 | 857.00 ± 44.0 |
* Values are means of 3 replicate samples (n = 3). Data are presented as the mean ± SEM.