Table 1.

Time-course of anticonvulsant effects of compounds (1a–30a) against maximal electroshock-induced seizure (MES)-induced seizures in mice. Data is presented as the number of animals protected against maximal electroshock (MES)-induced seizures out of eight animals per group. The MES test was performed at various pretreatment times (15, 30, 60, 120 min) after systemic administration of the investigated compounds in a fixed dose of 300 mg/kg. p-number of animals protected against MES-induced seizures; t-number of animals tested. “*” - Substance administered at a dose of 300 mg/kg produced acute neurotoxic effects in mice and it was impossible to determine its anticonvulsant action in the mouse MES model.

Compounds	Pretreatment Time (min)
	15	30	60	120
	p/t (%)	p/t (%)	p/t (%)	p/t (%)
1a	0/8 (0)	0/8 (0)	1/8 (12.5)	1/8 (12.5)
2a	0/8 (0)	0/8 (0)	0/8 (0)	0/8 (0)
3a	*	*	*	*
4a	8/8 (100)	8/8 (100)	7/8 (87.5)	7/8 (87.5)
5a	0/8 (0)	0/8 (0)	1/8 (12.5)	1/8 (12.5)
6a	4/8 (50)	6/8 (75)	6/8 (75)	3/8 (37.5)
7a	0/8 (0)	0/8 (0)	0/8 (0)	0/8 (0)
8a	0/8 (0)	0/8 (0)	0/8 (0)	0/8 (0)
9a	0/8 (0)	0/8 (0)	0/8 (0)	1/8 (12.5)
10a	8/8 (100)	8/8 (100)	8/8 (100)	6/8 (75)
11a	1/8 (12.5)	1/8 (12.5)	1/8 (12.5)	0/8 (0)
12a	6/8 (75)	6/8 (75)	7/8 (87.5)	7/8 (87.5)
13a	8/8 (100)	8/8 (100)	8/8 (100)	8/8 (100)
14a	*	*	*	*
15a	6/8 (75)	8/8 (100)	8/8 (100)	7/8 (87.5)
16a	5/8 (62.5)	7/8 (87.5)	8/8 (100)	8/8 (100)
17a	0/8 (0)	0/8 (0)	1/8 (12.5)	0/8 (0)
18a	0/8 (0)	0/8 (0)	1/8 (12.5)	0/8 (0)
19a	0/8 (0)	0/8 (0)	0/8 (0)	0/8 (0)
20a	0/8 (0)	0/8 (0)	0/8 (0)	0/8 (0)
21a	0/8 (0)	0/8 (0)	0/8 (0)	0/8 (0)
22a	4/8 (50)	5/8 (62.5)	3/8 (37.5)	2/8 (25)
23a	0/8 (0)	0/8 (0)	0/8 (0)	0/8 (0)
24a	0/8 (0)	0/8 (0)	0/8 (0)	0/8 (0)
25a	0/8 (0)	0/8 (0)	0/8 (0)	0/8 (0)
26a	0/8 (0)	0/8 (0)	0/8 (0)	0/8 (0)
27a	0/8 (0)	0/8 (0)	0/8 (0)	0/8 (0)
28a	0/8 (0)	0/8 (0)	0/8 (0)	0/8 (0)
29a	0/8 (0)	0/8 (0)	0/8 (0)	0/8 (0)
30a	0/8 (0)	0/8 (0)	0/8 (0)	0/8 (0)