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Effect of 6a and 10a on affinity of γ-aminobutyric acid (GABA) to GABAA receptor.
| Treatment | Ki ± S.E. [nM] | IC50 ± S.E. [nM] |
|---|---|---|
| GABA | 96.6 ± 9.9 | 406.5 ± 42.0 |
| GABA + 6a (1 × 10−5 M) | 99.7 ± 11.6 | 370.3 ± 42.7 |
| GABA + 6a (1 × 10−6 M) | 108.0 ± 11.2 | 469.0 ± 55.9 |
| GABA + 6a (1 × 10−7 M) | 155.0 ± 16.5 | 496.0 ± 57.0 |
| GABA + 10a (1 × 10−5 M) | 112.3 ± 8.5 | 474.0 ± 36.2 |
| GABA + 10a (1 × 10−6 M) | 85.5 ± 1.5 | 358.5 ± 6.5 |
| GABA + 10a (1 × 10−7 M) | 107.0 ± 5.0 | 452.0 ± 22.0 |
